Wheel of Weinreb Amide Reactions

The wonderful Weinreb amide reactions!

The Weinreb amide aka Weinreb–Nahm amide (N-methoxy-N-methylamide) that can react with a variety of nucleophiles (say, organometallic reagents) is used in the Weinreb ketone synthesis.

Wheel of Weinreb amides: Click/tap to enlarge the image


Nu (on the infographic):

  1. Organolithium
  2. Lithium aluminum hydride (reducing agent)
  3. Diisobutylaluminum hydride (reducing agent)
  4. Phosphorus ylides or phosphoranes
  5. Organolithium
  6. Organolithium
  7. Organolithium
  8. Organomagnesium (Grignard reagents)


What other wheel(s) 🎡 of organic reactions would you like to see❓ Questions❓ Let Chemaficionado know in the comments below or at mychemistryhomework@gmail.com❗


Reference:

Valiulin, R. Organic Chemistry: 100 Must-Know Mechanisms; De Gruyter: Berlin, 2023.

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