How to Alkylate Amines - Part 1

Amine alkylation is an organic reaction typically between an alkyl halide (or an alcohol) and ammonia or an amine.


The reaction is poorly selective, often requiring separation of the products.

Question:

Predict the product(s) of the following reactions:



Click/tap to enlarge the image

Solution infographic:



Click/tap to enlarge the image

DMA = Dimethylaniline

Industrially, most alkylations are typically done using alcohols, not alkyl halides as alcohols are less expensive than alkyl halides and their alkylation does not produce salts, the disposal of which can be challenging.

Astonishing alkylation❓ Let Chemaficionado know in the comments below or at mychemistryhomework@gmail.com❗

References:

(1)    Ncert. Chemistry : Textbook for Class XII - Part.II; National Council Of Educational Research And Training: New Delhi.

(2)    Brown, C.; Ford, M. Higher Level Chemistry, 2nd ed.; Pearson Education: Harlow, Essex, 2014.

(3)    Amine alkylation. Wikipedia. https://en.wikipedia.org/wiki/Amine_alkylation.

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