How to Carry out a Multistep Synthesis – Part 3

Multistep synthesis is the artificial execution of multiple organic chemical reactions to obtain one or more products by physical and chemical manipulations.


Retrosynthetic analysis is a problem-solving approach in the organic syntheses, achieved by transforming a target molecule into simpler precursor structures regardless of any potential reactivity/interaction with reagents, and repeated until a simple or commercially available structure is reached, which can be used as a starting material to synthesize the target molecule.

Question:

How would you do the following transformations?



Click/tap here to enlarge the image

Solution infographic:



Click/tap here to enlarge the image

A free-radical substitution reaction is usually initiated by peroxide or light.

Let's keep in mind that any multistep synthesis is possible via several routes ❗Questions ❓ Let Chemaficionado know in the comments below or at mychemistryhomework@gmail.com❗

References:

(1)    Wikipedia Contributors. Chemical synthesis. Wikipedia. https://en.wikipedia.org/wiki/Chemical_synthesis.

‌(2)    Retrosynthetic analysis. Wikipedia. https://en.wikipedia.org/wiki/Retrosynthetic_analysis.

(‌3)    Wikipedia Contributors. Radical substitution. Wikipedia.

(4)    Wikipedia Contributors. Sulfuryl chloride. Wikipedia.

‌(5)    Wikipedia Contributors. Wohl–Ziegler bromination. Wikipedia. https://en.wikipedia.org/wiki/Wohl%E2%80%93Ziegler_bromination.

(‌6)    Chouhan, M. S. Advanced Problems in Organic Chemistry for JEE, 11th Ed.

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