How to Predict where an Electrophilic Aromatic Substitution May Occur in a Ring – Part 8

An organic reaction in which an atom attached to an aromatic system (usually hydrogen) is substituted by an electrophile is referred to as electrophilic aromatic substitution (SEAr or EAS).


One of the most important EASs is nitration. Let's keep in mind that the presence of an activating group on the ring may complicate nitration.

Question:

Predict the major product(s) of the following reactions:



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Solution infographic:



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Eerie EAS chemistry❓ Let Chemaficionado know in the comments below or at mychemistryhomework@gmail.com❗

References:

(1)    Wikipedia Contributors. Electrophilic aromatic substitution. Wikipedia. https://en.wikipedia.org/wiki/Electrophilic_aromatic_substitution.

(2)    Brown, C.; Ford, M. Higher Level Chemistry, 2nd ed.; Pearson Education: Harlow, Essex, 2014.

‌(3)    Electrophilic aromatic directing groups. Wikipedia. https://en.wikipedia.org/wiki/Electrophilic_aromatic_directing_groups.

(4)    Nitration. Wikipedia. https://en.wikipedia.org/wiki/Nitration.

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