Wheel of Umpolung

Umpolung or polarity inversion/reversal is the chemical modification of a functional group that allows its secondary reactions that would otherwise not be feasible.


An umpolung tactics is typically used during retrosynthetic analysis.




Wheels of umpolung: Click/tap to enlarge the images

Die Umpolung has been used in Corey-Seebach or Seebach reactions. A Michael acceptor may be used as well.

What other wheel(s) 🛞 of organic reactions would you like to see ❓Let Chemaficionado know in the comments below or at mychemistryhomework@gmail.com❗

References:

(1)    ChemInfoGraphic. ChemInfoGraphic. https://cheminfographic.wordpress.com/.

(2)    Wikipedia Contributors. Umpolung; Wikimedia Foundation, 2024.

(3)    Brown, C.; Ford, M. Higher Level Chemistry, 2nd ed.; Pearson Education: Harlow, Essex, 2014.

(4)    Ncert. Chemistry : Textbook for Class XI - Part.II; National Council Of Educational Research And Training: New Delhi.

(5)    Graham, T. W.; Fryhle, C. B.; Snyder, S. A. Organic Chemistry.; Hoboken, Nj John Wiley Et Sons, Inc, 2016.

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