How to Carry out a Multistep Synthesis – Part 8

Multistep synthesis is the artificial execution of multiple organic chemical reactions to obtain one or more products by physical and chemical manipulations.


Retrosynthetic analysis is a problem-solving approach in the organic syntheses, achieved by transforming a target molecule into simpler precursor structures regardless of any potential reactivity/interaction with reagents, and repeated until a simple or commercially available structure is reached, which can be used as a starting material to synthesize the target molecule.

Question:

How would you carry out the following transformation?



Click/tap here to enlarge the image

Solution infographic:



Click/tap here to enlarge the image

SEAr = Electrophilic aromatic substitution

Let's keep in mind that any multistep synthesis is possible via several routes ❗Questions ❓ Let Chemaficionado know in the comments below or at mychemistryhomework@gmail.com❗

References:

(1)    Wikipedia Contributors. Chemical synthesis. Wikipedia. https://en.wikipedia.org/wiki/Chemical_synthesis.

‌(2)    Retrosynthetic analysis. Wikipedia. https://en.wikipedia.org/wiki/Retrosynthetic_analysis.

(3)    Brown, C.; Ford, M. Higher Level Chemistry, 2nd ed.; Pearson Education: Harlow, Essex, 2014.

(4)    Ncert. Chemistry : Textbook for Class XI - Part.II; National Council Of Educational Research And Training: New Delhi.

(5)    Graham, T. W.; Fryhle, C. B.; Snyder, S. A. Organic Chemistry.; Hoboken, Nj John Wiley Et Sons, Inc, 2016.

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